产品介绍
Product Description
Application
7-Benzyloxy-4-trifluoromethylcoumarin has been used:
- in the SBAD2-3x-AAGLY hepatocyte-like cell (HLC) functional assay to measure the cytochrome P450 3A4 (CYP3A4)-dependent activity
- in O-dealkylation reaction to determine the activity of CYP3A
- to measure the activity of CYP3A-mediated 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase activity (BFCOD)
Biochem/physiol Actions
Metabolized primarily by cytochrome P450 isozymes CYP1A2 and CYP3A4.
Legal Information
Supplied by Gentest Corp., U.S. Patent Nos. 6,207,404.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥99% (HPLC) |
| form | solid |
| storage temp. | −20°C |
| SMILES string | FC(F)(F)C1=CC(=O)Oc2cc(OCc3ccccc3)ccc12 |
| InChI | 1S/C17H11F3O3/c18-17(19,20)14-9-16(21)23-15-8-12(6-7-13(14)15)22-10-11-4-2-1-3-5-11/h1-9H,10H2 |
| InChI key | WVKLERKKJXUPIK-UHFFFAOYSA-N |
| Gene Information | rat ... Maoa(29253), Maob(25750) |
