Application
Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.
Biochem/physiol Actions
Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Dopamine D1-receptor agonist; Antihypertensive
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to tan |
| mp | 271 °C (lit.) |
| solubility | DMSO: ≥15 mg/mL at ~60 °C |
| storage temp. | room temp |
| SMILES string | CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23 |
| InChI | 1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4) |
| InChI key | CVKUMNRCIJMVAR-UHFFFAOYSA-N |
| Gene Information | human ... DRD1(1812) |
