产品介绍
Product Description
Biochem/physiol Actions
Cell penetrant, potent and non-toxic activity-based probe for deubiquitinase UCHL1; chemogenomic probe suitable for the cellular study of UCHL1.
GK13S is a cell penetrant, potent and non-toxic activity-based probe for deubiquitinase UCHL1. GK13S, but not GK16S, led to the reduction of monoubiquitin levels in the human glioblastoma cell line U-87 MG. GK13S together with GK16S comprises a set of chemogenomic probes for UCHL1, which is suitable for investigation of cellular functions of UCHL. GK13S also binds to PARK7, C21orf33, ISOC1 andNIT2.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | [n]2(cnc(c2)NC(=O)[C@@H]3CN(CC3)C#N)c1ccc(cc1)C(=O)NCCCC#C |
| InChI | 1S/C21H22N6O2/c1-2-3-4-10-23-20(28)16-5-7-18(8-6-16)27-13-19(24-15-27)25-21(29)17-9-11-26(12-17)14-22/h1,5-8,13,15,17H,3-4,9-12H2,(H,23,28)(H,25,29)/t17-/m0/s1 |
| InChI key | LSHAYFDZIOIKII-KRWDZBQOSA-N |
