Application
Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.
Biochem/physiol Actions
EGFR tyrosine kinase inhibitor.
Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.
Features and Benefits
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Preparation Note
Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.
| Quality Level | 200 |
| assay | ≥98% |
| form | solid |
| potency | >1250 μM IC50 (negative control) |
| mp | 113-116 °C (lit.) |
| solubility | chloroform: soluble 50 mg/mL, clear, light yellow,DMSO: soluble |
| storage temp. | 2-8°C |
| SMILES string | COc1ccc(cc1)\C=C(/C#N)C#N |
| InChI | 1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3 |
| InChI key | UOHFCPXBKJPCAD-UHFFFAOYSA-N |
| Gene Information | human ... EGFR(1956) |
