产品介绍
Product Description
Biochem/physiol Actions
Potent and selective BCL6 inhibitor that targets BTB domain with high-affinity.
BI-3812 is a potent and selective BCL6 inhibitor that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay) that inhibits BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM). Unlike BI-3802, BI-3812 does not induce BCL6 proteasomal degradation.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C1C(OCC(NC)=O)=CC2=C(N1C)C(OC)=CC(NC3=NC(N4CCC(CC4)C(N(C)C)=O)=NC=C3Cl)=C2 |
