Application
Theaflavin 3,3′-digallate is suitable for use to study its effects on the proliferation of chondrocytes in osteoarthritis (OA) rat model.
Biochem/physiol Actions
Theaflavin-3,3′-digallate (TFDG) is a polyphenol obtained from the leaves of Camellia sinensis. It is an ingredient of black tea that exhibits anti-inflammatory, antioxidant, anticancer, and antiviral activities. Theaflavins (TFs) exhibit significant potential as antimicrobial agents. TFDG is a promising broad-spectrum antibacterial and anti-spore agent effective against Gram-positive and Gram-negative bacteria, acid-fast bacteria, and endospores. It is a potent ligand of the SARS-unique domain (SUD) of nsp3 that disrupted the SUD-guanine quadruplex interactions. Theaflavin 3,3’-digallate potently inhibits SARS-CoV-2 replication in Vero E6-TMPRSS2 cells.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | , Light orange to very dark red |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=C1C(C(O)=C(O)C=C2[C@@H]3[C@H](OC(C4=CC(O)=C(O)C(O)=C4)=O)CC(C(O)=CC(O)=C5)=C5O3)=C2C=C([C@H]6OC(C=C(O)C=C7O)=C7C[C@H]6OC(C8=CC(O)=C(O)C(O)=C8)=O)C=C1O |
