产品介绍
Product Description
Application
6-Thio-2′-Deoxyguanosine has been used in secreted luciferase enzyme activity in tonsillar cancer cells.
Biochem/physiol Actions
6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres.
6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. 6-Thio-2′-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| color | white to brown |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| SMILES string | S=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)O3)C=N2)N=C(N)N1 |
| InChI | 1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5-,6-/m1/s1 |
| InChI key | SCVJRXQHFJXZFZ-HSUXUTPPSA-N |
