General description
TLE3 is known to function as a transcriptional coregulator of adipogenesis. It interacts with HESX1 and PROP1 to regulate transcriptional expression.
Rabbit Anti-TLE3 antibody recognizes human, zebrafish, rat, mouse, and canine TLE3.
Immunogen
Synthetic peptide directed towards the N terminal region of human TLE3
Application
Rabbit Anti-TLE3 antibody can be used for western blot applications at a concentration of 2.5μg/ml.
Biochem/physiol Actions
The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. These genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway which controls a number of different cell-fate choices in invertebrates and vertebrates.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: GSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRA
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 83 kDa |
| species reactivity | pig, dog, human, bovine |
| concentration | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_005069 |
| UniProt accession no. | Q04726 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... TLE3(7090) |
