产品介绍
Product Description
Application
5-氟尿嘧啶被用于诱导细胞凋亡。它被用作化学增敏剂。
Biochem/physiol Actions
一种有效的抗肿瘤药物，通过抑制胸苷酯合成酶来影响嘧啶的合成，从而耗尽细胞内的dTTP池。其代谢产物为核糖核酸和脱氧核糖核酸，可与RNA和DNA结合。用5-FU处理细胞可导致细胞在S-期积累，并已被证明其可诱导p53依赖的凋亡。
技术参数
Specifications
| Quality Level | 200 |
| assay | ≥99% (HPLC) |
| form | powder |
| technique(s) | titration: suitable |
| color | white |
| mp | 282-286 °C (dec.) (lit.) |
| solubility | 1 M NH4OH: soluble,DMSO/DMF: soluble,methanol: soluble |
| εmax | 7.07 at 265 nm in 0.1 M HCl |
| application(s) | diagnostic assay manufacturing hematology histology |
| storage temp. | room temp |
| SMILES string | FC1=CNC(=O)NC1=O |
| InChI | 1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) |
| InChI key | GHASVSINZRGABV-UHFFFAOYSA-N |
| Gene Information | human ... TYMS(7298) |
