Biochem/physiol Actions
Leucinostatins A and B are the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus.
Leucinostatins A and B are the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus. Leucinostatins display broad bio-activity against gram-positive bacteria, fungi, plants and tumor cell lines. They play a role as uncouplers in the inner mitochondria membrane and inhibit mitochondrial ATP synthesis. Recently, interest in Leucinostatins has focused on other aspects such as understanding their activity: insulin-like growth factor I regulators, ionophore, inhibitors of cell surface expression of viral glycoproteins and their potent in vitro and in vivo anti-trypanosomal activity.
Preparation Note
Mixture of Leucinostatin A (Cas# 76600-38-9 / MF: C62H111N11O13) and Leucinostatin B (Cas# 76663-52-0 / MF: C61H109N11O13).
Other Notes
Mixture of Leucinostatin A (Cas# 76600-38-9 / MF: C62H111N11O13) and Leucinostatin B (Cas# 76663-52-0 / MF: C61H109N11O13).
Stable at −20 °C for at least 2 years.
| Quality Level | 200 |
| biological source | (Paecilomyces lilacinus) |
| assay | ≥95% (mixture of Leucinostatin A+B, HPLC) |
| form | powder |
| solubility | DMF: 10 mg/mL,DMSO: 10 mg/mL,ethanol: 10 mg/mL,methanol: 10 mg/mL |
| storage temp. | −20°C |
