General description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
Immunogen
A synthetic methylated peptide corresponding to residues surrounding K9 of human histone H3
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
| biological source | rabbit |
| Quality Level | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 15 |
| species reactivity | human, mouse, rat |
| concentration | 3.78 mg/ml |
| technique(s) | ChIP: 1:50-1:200,immunofluorescence: 1:50-1:200,immunohistochemistry: 1:50-1:200,immunoprecipitation (IP): 1:50-1:200,western blot: 1:500-1:2000 |
| UniProt accession no. | Q16695 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | dimethylation (Lys9) |
| Gene Information | human ... H3-4(8290) |
