General description
Validamycin A (VMA) is a fungicidal antibiotic produced by Streptomyces hygroscopicus. It is an amino glycoside compound characterized by a sugar moiety without an amino group.
Application
Validamycin A may be used for evaluating its anti-seizure effectiveness in zebrafish larval epilepsy model; and studying its potential to induce plant defense responses and controlling fungal diseases.
Biochem/physiol Actions
Validamycin A is a potent and competitive inhibitor of Rhizoctonia solani trehalase. Validamycin A is used to protect rice plants against sheath blight caused by R.solani. Validamycin A in combination with amphotericin B appears to be effective against Aspergillus flavus strains resistant to amphotericin B. It is also efficient in controlling bacterial wilt intomatoes caused by P. solanacearum.
| biological source | Streptomyces hygroscopicus |
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
