产品介绍
Product Description
Biochem/physiol Actions
VU0405601 is a hERG (the human Ether-à-go-go-Related Gene) agonist that increased the IC50 of dofetilide from 38.7 nM to 76.3 nM. VU0405601 protects against arrhythmias induced by hERG inhibition.
VU0405601 is a hERG agonist that protects against arrhythmias induced by hERG inhibition.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | BrC1=C2C=CC=CC2=CC=C1OCC(NC3=CC=CN=C3)=O |
| InChI | 1S/C17H13BrN2O2/c18-17-14-6-2-1-4-12(14)7-8-15(17)22-11-16(21)20-13-5-3-9-19-10-13/h1-10H,11H2,(H,20,21) |
| InChI key | WLLRAGBPCSOJNH-UHFFFAOYSA-N |
