Biochem/physiol Actions
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1.
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.
Features and Benefits
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| Quality Segment | 100 |
| assay | ≥97% (chiral, HPLC) |
| form | solid |
| solubility | DMSO: >10 mg/mL,H2O: <2 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1 |
| InChI | 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1 |
| InChI key | ABIVOOWWGYJNLV-JTQLQIEISA-N |
