Ru265，5MG，SML2991-5MG，Sigma

Biochem/physiol Actions

Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca²⁺] (mCa²⁺), but not cytosolic [Ca²⁺] (cCa²⁺) transient (50 ?M; HeLa) by blocking MCU-mediated mCa²⁺ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa²⁺ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa²⁺ overload.
Selective mitochondrial calcium uniporter (MCU) inhibitor that blocks mitochondrial Ca²⁺ uptake at a >10-fold greater potency as Ru360.