规格
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Product Line:
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Pierce™ |
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Crosslinker Type:
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Homobifunctional |
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Labeling Method:
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Chemical Labeling |
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Reactive Moiety:
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Imidoester |
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Solubility:
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Water |
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Spacer:
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Mid-Length |
储存
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Store desiccated at 4°C. Shipped at ambient temperature. |
Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of an 8-atom spacer arm.
Features of dimethyl suberimidate:
• Reactive groups: imidoester (both ends)
• Reactive towards: amino groups (primary amines)
• Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins
Product References
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
DMA (dimethyl adipimidate)
DMP (dimethyl pimelimidate)
DTBP (Wang and Richard's Reagent)
