规格
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Accession Number:
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NP_000236.2 |
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Protein Form:
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Recombinant, Active, Cytoplasmic, Mutant |
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Shipping Condition:
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Dry Ice |
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Molecular Weight:
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75.4 kDa |
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Validated Application:
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Kinase Assay |
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Expression System:
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Insect |
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KinaseFamily:
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METs (HGFRs) |
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Protein Length:
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aa 956 - 1390 |
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Protein Tag:
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GST Tag |
储存
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Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol |
This MET (cMET) Y1235D recombinant human protein (956–end) was expressed in insect cells. MET receptor tyrosine kinase is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kDa (alpha) and 145 kDa (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue. Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovarian cancers and has been shown to be involved in tumor cell migration and invasion. MET (Y1235D) is one of the native mutant forms of MET. MET (cMET) Y1235D recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
