Clone REA833 recognizes the human CD43 antigen, also known as leukosialin, a cell surface sialoglycoprotein that is involved in cell adhesion, differentiation, and activation. The CD43 antigen is expressed on most leukocytes, i.e., T cells, NK cells, granulocytes, monocytes, and macrophages, on hematopoietic stem cells and on platelets, but not on erythrocytes. Among B cells, CD43 is expressed on activated B cells and plasma cells but not on resting B cells, e.g., naive B cells. In bone marrow, CD43 is found on pro–B cells but is down-regulated during transition to the pre–B cell stage. CD43 is expressed on different myeloid and lymphoid tumors, including some B cell malignancies.
Additional information: Clone REA833 displays negligible binding to Fc receptors.
Spn, Leukosialin, GALGP, gpL115, Lsn, Sialophorin
Technical specifications
