Clone MEL14-H2.100 recognizes mouse CD62L, a member of the selectin family of cell adhesion molecules also know as L-selectin. CD62L is important for the homing of lymphocytes to peripheral lymph nodes through high endothelial venules. It also contributes to leukocyte emigration into acute inflammatory sites. CD62L is a glycoprotein expressed on the cell surface of most thymocytes, T cells, B cells, monocytes, dendritic cells, neutrophils, and eosinophils. It is highly expressed on naive T cells and down-regulated upon differentiation due to activation-dependent shedding. CD62L is also expressed on a subset of CCR7highCD44high central memory T cells and on CD4+CD25+ regulatory T cells.
Sell, L-selectin, LECAM-1, Lnhr, Ly-22, Ly-m22, Lyam-1, Lyam1, LAM-1
Technical specifications
