产品介绍
Product Description
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规格 |
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| Accession Number: | NP_004949.1 |
| Kinase Group: | Ser⁄Thr Kinases: Atypical |
| Shipping Condition: | Dry Ice |
| System Compatibility: | LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™ |
| Target Entry: | mTOR, FRAP1 |
| Target Gene: | FK506 binding protein 12-rapamycin associated protein 1 |
| Expression System: | Baculovirus |
| Form: | Frozen |
| Protein Form: | Recombinant, Catalytic |
| Protein Subtype: | Serine⁄Threonine Kinases |
| Research Category: | Signal Transduction, Drug Development, Oncology |
| Species: | Human |
| Validated Application: | Kinase Assay |
| Molecular Weight: | 163.9 kDa |
| Gene Alias: | FRAP1 (mTOR) |
| KinaseFamily: | PIKK Kinase Family |
| Protein Length: | aa 1360-2549 |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.1% Polysorbate 20, 2 mM DTT, 50% Glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
FRAP1 (mTOR) is a serine⁄threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR⁄PI3-kinase⁄AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics.
