Clone REAL1010 is an antibody fragment derived from the full RRM2 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1010 recognizes RRM2, also known as Ribonucleotide reductase M2, which is one of the two different subunits of ribonucleotide reductase. RRM2 is a rate-limiting enzyme involved in DNA repair and synthesis, that catalyzes the biosynthesis of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. RRM2 plays an active role in tumor progression and metastasis. It is frequently overexpressed in cancer, including glioblastoma, oral squamous cell carcinoma (OSCC) and gastric cancer and is identified as a therapeutic target.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
Ribonucleotide reductase M2, RR2, RR2M
Technical specifications
