产品介绍
Product Description
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规格 |
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| Accession Number: | NP_940980.2, G2019S |
| Form: | Frozen |
| Kinase Group: | Ser⁄Thr Kinases: TKL Group |
| Protein Form: | Catalytic |
| Research Category: | Drug Development |
| Shipping Condition: | Dry Ice |
| Species: | Human |
| Molecular Weight: | 204.9 kDa |
| Quantity: | 1mg |
| Gene Alias: | LRRK2 G2019S |
| Validated Application: | Kinase Assay |
| Expression System: | Baculovirus |
| KinaseFamily: | LRRK Kinase Family |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease. The G2019S mutation of LRRK2 is associated with an increase in catalytic activity.
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
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• LanthaScreen® Activity Assay
