Clone REA648 recognizes the CD271 antigen, a type I transmembrane glycophosphoprotein, also known as low-affinity nerve growth factor receptor (LNGFR) or p75 neurotrophin receptor (p75 NTR). CD271 belongs to the low-affinity neurotrophin receptors and the tumor necrosis factor receptor superfamily. Initially the human CD271 was described to be expressed on cells of the central and peripheral nervous system, and was suggested to be involved in the development, survival, and differentiation of cells. Binding of neutrophins to the CD271 receptor initiates the stimulation of neuronal cells to survive and differentiate. CD271 is expressed on mesenchymal stem/stromal cells (MSCs), follicular dendritic cells, mesenchymal cells involved in mesenchymal-epithelial interactions, autonomic and sensory neurons, oligodendrocytes, astrocytes, schwann cells, and neural crest stem cells.
Additional information: Clone RE648 displays negligible binding to Fc receptors.
NGFR (p75), p75NGFR, p75NTR, TNFRSF16, CD271, Gp80-LNGFR
Technical specifications
