规格
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Accession Number:
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NP_940980.3 |
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Expression System:
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Baculovirus |
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Protein Form:
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Full Length |
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Research Category:
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Neurobiology |
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Species:
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Human |
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Validated Application:
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Kinase Assay |
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Gene ID (Entrez):
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120892 |
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Molecular Weight:
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288 kDa |
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Quantity:
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10μg |
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Gene Alias:
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AURA17, DARDARIN, PARK8, RIPK7, ROCO2 |
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KinaseFamily:
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LRRK Kinase Family |
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Protein Tag:
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DYKDDDDK |
储存
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Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase. |
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multi-domain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active wild-type LRRK2 protein may be useful in research to better understand the native protein, unaffected by mutations, as well as to explore the mechanisms underlying the disease.
• Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds or hits specific to the full-length form
• Advance Parkinson's research using the full-length protein and validated assays
Related Links:
LRRK2 Tools for Advancing Parkinson's Disease Research
LanthaScreen® Kinase Activity Assay
LanthaScreen® Eu Kinase Binding Assay
