产品介绍
Product Description
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规格 |
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| Accession Number: | NP_940980.2, G2019S |
| Assay Entry: | Biochemical ADP accumulation, Biochemical terbium phospho-specific activity, Biochemical binding/kinetic |
| Kinase Group: | Ser⁄Thr Kinases: TKL Group |
| Protein Form: | Recombinant, Catalytic |
| Research Category: | Signal Transduction, Neurobiology |
| Shipping Condition: | Dry Ice |
| Species: | Human |
| System Compatibility: | LanthaScreen® Antibody, LanthaScreen® Substrate, Adapta™ |
| Target Entry: | LRRK2 G2019S |
| Target Gene: | Leucine-rich repeat kinase 2 |
| Gene ID (Entrez): | 120892 |
| Molecular Weight: | 204.9 kDa |
| Quantity: | 10μg |
| Protein Subtype: | Serine⁄Threonine Kinases |
| Gene Alias: | LRRK2 G2019S |
| Validated Application: | Kinase Assay |
| Protein Family: | Kinases & Inhibitors |
| Expression System: | Baculovirus |
| KinaseFamily: | LRRK Kinase Family |
| Protein Length: | aa 970-2527; G2019S |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease. The G2019S mutation of LRRK2 is associated with an increase in catalytic activity.
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® Activity Assay
