Clone REA494 recognizes the human osteoclast-associated immunoglobulin-like receptor (OSCAR) antigen, a 45 kDa single-pass type I membrane protein also known as polymeric immunoglobulin receptor 3 (PIgR-3). OSCAR is a member of the leukocyte receptor complex (LRC) protein family and is an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. OSCAR expression is detected in preosteoclasts or mature osteoclasts. Osteoclasts are terminally differentiated leukocytes that erode the mineralized bone matrix. These cells originate from hematopoietic precursors and share a common progenitor with macrophages and dendritic cells. Human OSCAR is also expressed at all stages of myeloid dendritic cell maturation, on in vitro derived macrophages, granulocytes, and monocyte derived dendritic cells.
Additional information: Clone REA494 displays negligible binding to Fc receptors.
PIgR3, PIgR-3, hOSCAR
Technical specifications
