Clone REA324 recognizes the signal transducer and activator of transcription 3 (STAT3) antigen phosphorylated at serine 727 (pS727). STAT3 expression is found ubiquitously. It is activated in response to various growth factors, hormones, and cytokines, and has an important role in their signaling. When these ligands bind to the specific transmembrane STAT3 receptor, STAT3 becomes activated by tyrosine phosphorylation of two important phosphorylation sites, pY705 and pS727. The dimeric STAT3 translocates to the nucleus, where it binds to consensus STAT3 binding sequences within the promoter region of target genes and thereby activates their transcription. The persistent activation of STAT3 also mediates tumor-promoting inflammation. STAT3 promotes pro-oncogenic inflammatory pathways in tumor inflammation and immunity, including nuclear factor-κB and interleukin-6-GP130-Janus kinase pathways, and by opposing STAT1- and NF-κB-mediated T helper 1 anti-tumor immune responses.
Additional information: Clone REA324 displays negligible binding to Fc receptors.
ADMIO, APRF, HIES
Technical specifications
