Clone 541-10B2 recognizes the human CD146 antigen, also known as MUC18, MCAM, Mel‑CAM, or S-endo. CD146 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and contains five extracellular immunoglobulin (Ig)–like domains. CD146 possesses a limited tissue expression distribution, including endothelial cells, pericytes, smooth muscle cells, follicular dendritic cells, melanoma cells, and a sub-population of activated T lymphocytes. CD146 is also expressed on marrow stromal cells (MSCs).
CD146 functions as a Ca2+-independent cell adhesion molecule that is involved in heterophilic cell-cell interactions, and may be involved in the extravasion and/or homing of activated T cells. CD146 expression in melanoma is also directly associated with tumor growth and metastasis.
MCAM, MUC18, Endo-CAM, Mel-CAM, S-endo
Technical specifications
