General description
Calmodulin purifed from human brain.
Calmodulin purifed from human brain. Calmodulin is a ubiquitous Ca2+-binding protein distributed in eukaryotic cells that serves as a major physiological effector for a wide range of cellular responses. The Ca2+-calmodulin complex is involved in the maintenance of intracellular Ca2+ homeostasis, as well as in the regulation of the intracellular concentration of other second messengers, such as cyclic AMP and inositol trisphosphate.
Physical form
Lyophilized from protein solution with 2 mM EDTA.
Preparation Note
Reconstitute with distilled water. H₂O (1 mg/ml)
Other Notes
O′Neil, K.T., and DeGrado, W.F. 1990. Trends Pharmacol. Sci.15, 59.
Gopalakrishna, R., and Anderson, W.B. 1982. Biochem. Biophys. Res. Commun.104, 830.
Sharma, R.K., and Wang, J.H. 1979. Adv. Cyclic Nucleotide Res.10, 187.
One unit is defined as the amount of calmodulin that will give rise to 50% of the maximal enzyme activation of a standard level of activator-deficient 3ʹ,5ʹ-cyclic nucleotide phosphodiesterase.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (native PAGE) |
| form | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| storage temp. | −20°C |
