General description
Stathmin-like 2 (STMN2) protein is a phospho-protein and functions in microtubule dynamics and signal transduction. Studies show STMN2 plays a regulatory role in neuronal growth and thought to be involved in osteogenesis. Reduced levels, i.e. reduction in expression, have been associated with Down′s syndrome and Alzheimer′s disease. Data also suggests that STMN2 may play a role in modulating membrane interaction with the cytoskeleton during neurite outgrowth.
~21 kDa observed
Immunogen
Epitope: C-terminus
Linear peptide corresponding to the C-terminus of rat STMN2.
Application
Detect STMN using this mouse monoclonal antibody, Anti-STMN2 Antibody, clone L5/1 validated for use in western blotting, IHC & ICC.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected STMN2 in 10 µg of rat fetal brain (E16) tissue lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected STMN2 in rat hippocampus tissue.
Immunocytochemistry Analysis: A representative lot detected STMN2 in cultured hippocampal neurons (Prof. J. Trimmer, University of Califnornia, Davis.).
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in SH-SY-5Y cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected STMN2 in 10 µg of SH-SY-5Y cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | L5/1, monoclonal |
| species reactivity | rat, human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable,immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG2bκ |
| NCBI accession no. | NP_445892 |
| UniProt accession no. | P21818 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | rat ... Stmn2(84510) |
