产品介绍
Product Description
General description
A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 440 nM).
Biochem/physiol Actions
Cell permeable: no
Product competes with ATP.
Reversible: no
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥97% (HPLC) |
| form | solid |
| potency | 11 nM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | light orange |
| solubility | DMSO: 10 mg/mL,ethanol: 10 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | Clc1c(cccc1)c2c3c(c4c([nH]c5c4cc(cc5)O)c2)[c]([nH][c]3=O)=O |
| InChI | 1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26) |
| InChI key | DPEXRCOBPACFOO-UHFFFAOYSA-N |
