Application
Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in 0.
Biochem/physiol Actions
Dopamine b-HydroxylaseDBH is a single gene product that exists as a cytosolic enzyme, as a membrane protein and is secreted into the circulation (Lewis & Asnani, 1992). Because of its residence time as a plasma membrane-bound protein, it is able to be used as a targeting agent for neurons. The target neurons include postganglionic sympathetic neurons and all noradrenergic and adrenergic neurons of the central nervous system. As such anti-DBH-SAP can be used for the production of acute peripheral autonomic failure in a model for the human disease. It can also be used for the analysis of the behavioral effects of noradrenergic or adrenergic ablation. When injected intraventricularly, noradrenergic neurons of the locus coeruleus are eliminated (Wiley & Lappi, 1994). The antibody and immunotoxin undergo retrograde transport.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | saporin |
| antibody product type | primary antibodies |
| clone | 4F10.2, monoclonal |
| species reactivity | rat |
| packaging | antibody small pack of 25 μg |
| manufacturer/tradename | Chemicon® |
| technique(s) | immunolesioning: suitable |
| isotype | IgG1 |
| NCBI accession no. | NM_000787.3 |
| UniProt accession no. | P09172 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | rat ... Dbh(25699) |
