产品介绍
Product Description
General description
γ-氨基丁酸（GABA）是哺乳动物中枢神经紧张的系统中主要的抑制性神经递质。GABA通过离子型[GABA（A/C）]受体发挥其作用，以产生快速的突触抑制，而代谢型[GABA（B）]受体则产生缓慢，延长的抑制信号。GABA（B）受体由两个相关的7跨膜受体GABA（B）受体1和GABA（B）受体2的异二聚体组成。GABA（B）受体1基因被定位到靠近HLA-F基因的HLA I类区域内的染色体6p21.3。多发性硬化、癫痫和精神分裂症的易感基因座也已定位于该区域。该基因的可变剪接产生4个转录物变体。
尽管在计算的105 kDa分子量周围观察到一条条带，但由于该条带与存在的其他非特异性条带相比较弱，因此该抗体不推荐使用蛋白质印迹法。
Immunogen
在大鼠GABA-B-R2的C末端的牛甲状腺球蛋白偶联的线性肽。
Application
抗GABAB受体R2抗体是用于IH & WB的抗GABAB受体R2的抗体。
Biochem/physiol Actions
该抗体可识别大鼠GABA-B-R2的C端。
Analysis Note
对照
大鼠中脑区的浦肯野细胞
通过免疫组化对大鼠中脑区浦肯野细胞进行了评估。
免疫组化分析： 该抗体的1:300稀释液在大鼠中脑区域的浦肯野细胞中检测到GABA-B-R2。
Other Notes
替代品：AB5394
技术参数
Specifications
| biological source | guinea pig |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | serum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | rhesus macaque, rat |
| species reactivity (predicted by homology) | canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| NCBI accession no. | NP_113990 |
| UniProt accession no. | O88871 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... GABBR2(9568) |
