General description
Mercury (Hg) is considered an extremely toxic heavy metal which is extremely harmful to human health. Researchers are investigating the role of Hg2+-induced oxidative stress, via peroxynitrite (ONOO−) level upregulation, in the pathogenic mechanisms of mercury toxicity. BioTracker NIR-HO Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and visualization of Hg2+-induced ONOO− generation in vitro and in vivo. This fluorescent probe was designed with a “dual-key-and-lock” strategy where emission can only be switched on in the presence of both Hg2+ and ONOO− (1). It provides an effective method for detecting and imaging Hg2+ and ONOO- in oxidative stress studies and in the development of detoxifying drugs. Spectral PropertiesExcitation: 550 nmEmission: 680 nm
Application
Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Features and Benefits
Near-Infrared probe for imaging Hg2+-and ONOO− in mercury-induced oxidative stress studies.
Physical form
Lyophilized. Yellow solid.
Preparation Note
Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| form | lyophilized |
| mol wt | calculated mol wt 506.6 |
| packaging | pkg of 1 mg |
| manufacturer/tradename | Millipore |
| storage condition | protect from light |
| growth mode | N/A |
| shipped in | ambient |
| storage temp. | −20°C |
