General description
ADAM metallopeptidase domain 10 or A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein which is widely distributed. It consists of an amino-terminal signal sequence, a prodomain, a metalloprotease domain, a disintegrin domain, a cysteine-rich region, a transmembrane region and a cytoplasmic tail. The gene encoding this protein is localized on human chromosome 15q21.3.
Immunogen
ADAM10 antibody was raised against a peptide corresponding to amino acids 732 to 748 of human ADAM10. This sequence is identical to those of bovine and rat origins and differs from that of mouse ADAM10 by one amino acid (2,4).
Biochem/physiol Actions
ADAM metallopeptidase domain 10 (ADAM10) activates Notch proteins and has a role in embryonic development. It functions as a molecular scissor and cleaves the extracellular domains of proteins. The protein is a therapeutic target for a variety of diseases and malignancies.
Features and Benefits
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Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500181.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 85 kDa |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable,immunofluorescence: suitable,indirect ELISA: suitable,western blot: suitable |
| NCBI accession no. | NP_001101 |
| UniProt accession no. | O14672 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... ADAM10(102) |
