General description
CD300e / IREM-2 (immune receptor expressed by myeloid cells 2), also known as CLM2 or LMIR6, is a monomeric transmembrane glycoprotein with a single extracellular immunoglobulin-like domain. Intracellularly it associates with DAP-12, an ITAM-containing adaptor molecule. CD300e is expressed on mature monocytes and peripheral blood myeloid dendritic cells. Its crosslinking leads to release of pro-inflammatory cytokines, and increased expression of activation markers.
Immunogen
CD300e-HA-transfected cells
Biochem/physiol Actions
The mouse monoclonal antibody UP-H2 recognizes an extracellular epitope on CD300e / IREM-2, a 32 kDa glycoprotein expressed by mature monocytes and peripheral blood myeloid dendritic cells.
Physical form
Phosphate buffered saline (PBS), pH 7.4
Preparation Note
Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.
Other Notes
The antibody solution should be gently mixed before use.
| conjugate | unconjugated |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | UP-H2, monoclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| concentration | 1 mg/ml |
| technique(s) | FUNC: suitable,flow cytometry: suitable,immunoprecipitation (IP): suitable,western blot: suitable |
| isotype | IgG1κ |
| UniProt accession no. | Q496F6 |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CD300E(342510) |
