产品介绍
Product Description
Biochem/physiol Actions
KRA-333 is a potent and selective KRAS agonist that binds directly to the GTP/GDP binding pocket of KRAS preventing the cleavage of GTP into GDP and caucusing accumulation of activated GTP-KRAS and suppression of cell growth. KRA-333 promotes apoptosis and autophagic cell death of cancer cells and inhibits growth of mutant KRAS lung cancer in xenografts mice model.
Potent and selective KRAS agonist that binds directly to the GTP/GDP binding pocket caucusing accumulation of activated GTP-KRAS and suppression of cell growth
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C(O)C1=CC=C(CCCCNC(CBr)=O)C=C1 |
| InChI | 1S/C13H16BrNO3/c14-9-12(16)15-8-2-1-3-10-4-6-11(7-5-10)13(17)18/h4-7H,1-3,8-9H2,(H,15,16)(H,17,18) |
| InChI key | WZQJLTLURXNPQG-UHFFFAOYSA-N |
