General description
ULK4, or Unc-51-like kinase 4, is a Ser/Thr protein kinase that is a member of the APG1/unc-51/ULK1 subfamily. ULK4 contains five HEAT repeats and a catalytic kinase domain. The ULK4 gene is conserved in many species including chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, and rice. ULK4 has been implicated as a gene involved in the development of hydrocephalus. This neurologic disorder in animal models is being used to elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Preparation Note
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
| biological source | human |
| recombinant | expressed in baculovirus infected Sf9 cells |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~97 kDa |
| NCBI accession no. | NM_017886 |
| application(s) | cell analysis |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... ULK4(54986) |
