General description
Anti-TIE2 Antibody detects endogenous levels of total TIE2 protein.
The TIE2 (TEK receptor tyrosine kinase) gene is mapped to human chromosome 9p21.2. It is predominantly expressed in the Schlemm′s canal endothelial of the eye.
Immunogen
The antiserum was produced against synthesized peptide derived from human TIE2.
Immunogen Range: 1068-1117
Biochem/physiol Actions
Tie-2 (TEK receptor tyrosine kinase) protein induces angiogenesis (both developmental and tumor) and supports endothelial cell survival, upon binding of angiopoietin-1 (an endothelial growth factor) to the receptor. Tie-2 is necessary for Schlemm′s canal formation. The gene regulates vascular homeostasis by involving in auto or transphosphorylation.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 125 kDa |
| species reactivity | mouse, human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:5000,immunohistochemistry: 1:50-1:100 |
| NCBI accession no. | Q02763 |
| UniProt accession no. | Q02763 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... TEK(7010) |
