General description
Solute carrier family 18 member A2 (SLC18A2) or vesicular monoamine transporter 2 (VMAT2) is a transmembrane protein that acts at nerve terminals. It is expressed in platelets and in central, peripheral and enteric neurons. The gene encoding SLC18A2 consists of 16 exons and is localized on human chromosome 10q25.
Immunogen
Peptide with sequence C-SYPIGEDEESESD from the C Terminus of the protein sequence according to NP_003045.2.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Biochem/physiol Actions
Solute carrier family 18 member A2 (SLC18A2) modulates the release of neurotransmitters like dopamine, serotonin and γ-amino butyric acid. It has a role in the accumulation of neurotransmitters in synaptic vesicles to prevent toxicity. SLC18A2 has been linked to tardive dyskinesia and may be associated with Parkinson′s disease.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | goat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | rat, human |
| technique(s) | immunohistochemistry: suitable,indirect ELISA: suitable,western blot: suitable |
| UniProt accession no. | Q05940 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... SLC18A2(6571) |
