General description
RAD51 (RAD51 recombinase) belongs to the RecA/RadA/Rad51 protein family. It has a conserved ATP binding core. This protein is expressed in testis, ovary, and lymphoid tissue. It is located on human chromosome 15q15.
Immunogen
The antiserum was produced against synthesized peptide derived from human RAD51 around the phosphorylation site of Tyr315.
Immunogen Range: 281-330
Application
Anti-phospho-RAD51 (pTyr315) antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Biochem/physiol Actions
RAD51 (RAD51 recombinase) plays a major role in homology-directed repair (HDR) and cell viability.This gene acts an an important target for cancer therapy. RAD51 interacts with BRCA2 (breast cancer susceptibility protein) and participates in DSB (double strand DNA breaks) repair.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 36 kDa |
| species reactivity | rat, human, mouse |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:10000,western blot: 1:500-1:1000 |
| NCBI accession no. | Q06609 |
| UniProt accession no. | Q06609 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr315) |
| Gene Information | human ... RAD51(5888) |
