产品介绍
Product Description
Application
L-165,041 has been used as a peroxisome proliferator-activated receptor β/δ (PPARβ/δ) ligand to study its influence on PPARβ/δ mediated postnatal myogenesis in C2C12 myoblasts.
Biochem/physiol Actions
L-165041 dose-dependently blocks rat vascular smooth muscle cell (VSMC) proliferation and migration by inducing the cell cycle arrest. It has the potential to treat pathological cardiovascular conditions, such as restenosis and atherosclerosis. L-165041 also effectively inhibits the progression of diabetic nephropathy. It exhibits anti-apoptosis and anti-angiogenic effects.
PPARβ (PPARδ) selective agonist.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
技术参数
Specifications
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | protect from light,under inert gas |
| color | off-white |
| mp | 127-128 °C (lit.) |
| solubility | DMSO: >10 mg/mL |
| originator | GlaxoSmithKline |
| storage temp. | 2-8°C |
| SMILES string | CCCc1c(O)c(ccc1OCCCOc2ccc(OCC(O)=O)cc2)C(C)=O |
| InChI | 1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25) |
| InChI key | HBBVCKCCQCQCTJ-UHFFFAOYSA-N |
| Gene Information | human ... PPARD(5467) |
