General description
DYRK1A (N-terminal) encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-c
DYRK1A (dual-specificity tyrosine-phosphorylated regulated kinase 1A) is a member of a growing family of Ser/Thr protein kinases termed DYRKs.
The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.
Application
Anti-DYRK1A (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.
Biochem/physiol Actions
DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~86 kDa |
| species reactivity | rat, mouse, human |
| concentration | ~1.5 mg/mL |
| technique(s) | western blot: 1.5-3 μg/mL using rat brain embryonic extract (S1 fraction),western blot: 3-5 μg/mL using PC12 cell lyste |
| web metadata keyword.default | Anti-DYRK1A antibody 3-5 µg/mL PC12 cell lysate,Anti-DYRK1A antibody for immunohistochemistry,Anti-DYRK1A antibody rabbit 0.01 M PBS,Anti-DYRK1A antibody,Anti-DYRK1A protein kinase antibody manufacturer,Anti-Dual-specificity kinase 1A antibody procurement,Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A,Anti-MBN protein kinase antibody for western blot,DYRK1A N-terminal antibody immunoblotting,DYRK1A N-terminal antibody with sodium azide,DYRK1A antibody 1.5-3 µg/mL rat brain extract,DYRK1A antibody rabbit 15 mM sodium azide,high purity Anti-DYRK1A antibody for research,rabbit Anti-Dyrk1a antibody for lab use |
| UniProt accession no. | Q13627 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... DYRK1A(1859) mouse ... Dyrk1a(13548) rat ... Dyrk1a(25255) |
