General description
Brachyury (T) is an oncogene mapped to human chromosome 6q27. This gene codes for Brachyury, which is expressed throughout the primary mesoderm during the early stages of embryogenesis. Brachyury protein structure comprises highly conserved DNA binding domain, known as T-box domain.
Immunogen
synthetic peptide corresponding to an internal sequence of human brachyury (GeneID 6862). This sequence is 80% identical in mouse and 86% identical in rat.
Biochem/physiol Actions
Brachyury protein is a transcription factor that aids in the embryonic development of notochord tissue. It also plays an essential role in posterior mesoderm formation and differentiation. Brachyury is highly expressed in a variety of cancers including, chordoma and hemangioblastoma. It serves as an immunohistochemical marker for differential diagnosis of chordoma and hemangioblastoma (HBL).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | human, rat, mouse |
| concentration | ~1 mg/mL |
| technique(s) | immunohistochemistry: 1:100-1:250,western blot: 1:500-1:1,000 |
| UniProt accession no. | O15178 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... T(6862) mouse ... T(20997) rat ... T(292301) |
