产品介绍
Product Description
Biochem/physiol Actions
LFM-A13 is a potent and selective inhibitor of Bruton′s tyrosine kinase (BTK)
LFM-A13 is an inhibitor of the nonreceptor tyrosine kinase Bruton′s tyrosine kinase (Btk), a new molecular target for treatment of B-cell lymphoma and autoimmune disorders. LFMA13 inhibited recombinant BTK with an IC50 value of 2.5microM with 100-fold lower inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and CDK1, 2 and 3, as well as several other related kinases
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
技术参数
Specifications
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥19 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | C\C(O)=C(/C#N)C(=O)Nc1cc(Br)ccc1Br |
| InChI | 1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6- |
| InChI key | UVSVTDVJQAJIFG-VURMDHGXSA-N |
