DUB-IN-2，25MG，SML3942-25MG，Sigma

Biochem/physiol Actions

Potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor.

DUBs-IN-2 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 280 nM/USP8, >100 µM/USP7). DUBs-IN-2 inhibits the proliferation of gastric cancer (GC) cell NCI-N87 in cultures (IC50 = 480 nM post 3-day incubation) and NCI-N87-derived tumor growth in mice in vivo (2 mg/kg/d 5x per wk) by promoting HER-2 degradation.