General description
Adenomatosis polyposis coli down-regulated 1 (APCDD1) encodes a membrane bound glycoprotein. Apcdd1 is predominantly expressed in epidermal and dermal compartments of human hair follicles. In human chromosome, the gene APCDD1 is localized on 18p11.22.
Biochem/physiol Actions
Adenomatosis polyposis coli down-regulated 1 (APCDD1) inhibits wnt (wingless/integrated) signalling and promotes human hair growth. Mutations in APCDD1 results in a rare autosomal dominant hereditary hypotrichosis, which is characterized by hair loss due to hair follicle miniaturization. APCDD1 is directly regulated by β-catenin/T-cell factor 4 (TCF4). The high expression of Apcdd1 in colon cancer cells promotes its proliferation. APCDD1 is essential for adipocyte differentiation. Downregulation of APCDD1 in diet induced obesity impairs adipocyte differentiation and causes obesity related metabolic diseases.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 58797 Da |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:10-1:50,western blot: 1:1000 |
| NCBI accession no. | NP_694545.1 |
| UniProt accession no. | Q8J025 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... APCDD1(147495) |
