产品介绍
Product Description
Biochem/physiol Actions
Blood-brain barrier (BBB)-permeable formyl peptide receptor 1 (FPR1) antagonist with therapeutic efficacy in murine intracerebral hemorrhage (ICH) models in vivo.
T-0080 is a blood-brain barrier (BBB)-permeable formyl peptide receptor 1 (FPR1) antagonist that effectively inhibits fMLF-dependent response in human and murine neutrophils cultures (10 nM fMLF-induced human neutrophil Ca2+ response IC50 = 0.85 μM) and attenuates brain edema and improved neurological outcomes in murine intracerebral hemorrhage (ICH) models in vivo (5 mg/kg via daily i.p.) with no short-term adverse effects (up to 2 g/kg p.o.).
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C1N(C2CCOCC2)C(C3=CC=C(C(F)(F)F)C=C3)C4=C(C5=C(O)C=CC(C)=C5)NN=C41 |
| InChI | 1S/C24H22F3N3O3/c1-13-2-7-18(31)17(12-13)20-19-21(29-28-20)23(32)30(16-8-10-33-11-9-16)22(19)14-3-5-15(6-4-14)24(25,26)27/h2-7,12,16,22,31H,8-11H2,1H3,(H,28,29) |
| InChI key | NLNJUYHGBAJDBQ-UHFFFAOYSA-N |
