产品介绍
Product Description
Application
3,5-Dinitrocatechol (3,5-DNC) has been used in the preparation of the molybdenum (VI)-(3,5-DNC) complex. It has also been used as a catechol-O-methyltransferase (COMT) inhibitor and as a positive control for screening human COMT inhibition.
Chelating reagent used in a sensitive (μM) assay for vanadium.
Biochem/physiol Actions
Selective inhibitor of catechol O-methyl transferase (COMT); penetrates the blood brain barrier and is useful both orally and parenteraly in experiments where inhibition of COMT in the central nervous system is required.
Analysis Note
Solutions may be stored for several days at 4 °C.
Disclaimer
Photosensitive
技术参数
Specifications
| biological source | synthetic (organic) |
| Quality Segment | 200 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | yellow |
| mp | 168-170 °C |
| solubility | H2O: slightly soluble 0.17 mg/mL,45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.8 mg/mL,0.1 M HCl: slightly soluble,DMSO: soluble,aqueous buffer pH > 5: soluble,ethanol: soluble |
| storage temp. | 2-8°C |
| SMILES string | Oc1cc(cc(c1O)[N+]([O-])=O)[N+]([O-])=O |
| InChI | 1S/C6H4N2O6/c9-5-2-3(7(11)12)1-4(6(5)10)8(13)14/h1-2,9-10H |
| InChI key | VDCDWNDTNSWDFJ-UHFFFAOYSA-N |
| Gene Information | human ... COMT(1312) |
