产品介绍
Product Description
Application
Bisindolylmaleimide II (BIS II) has been used:
- as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes
- as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity
- as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells
Biochem/physiol Actions
Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.
技术参数
Specifications
| biological source | synthetic (organic) |
| Quality Segment | 200 |
| assay | ≥97% (Mixture of 2 isomers) |
| form | powder |
| solubility | DMSO: soluble,ethanol: soluble |
| shipped in | dry ice |
| storage temp. | −20°C |
| SMILES string | CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26 |
| InChI | 1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33) |
| InChI key | LBFDERUQORUFIN-UHFFFAOYSA-N |
